My own brick wall is a married couple, Uriah Couse (1810-1887) and Susan Fritts (1812-1891). I connect up to them through their daughter Emily, born 1834; the family genealogy put together by my late cousin Leonard Schmidt gives Emily's place of birth as Ledyard, Cayuga Co., NY, possibly because her parents appear there on the 1840 census with their first five children, all girls. We follow the family from there to Sheboygan Co, Wisconsin, where, according to a county history, "U. Cous" arrived in the town of Scott in 1847 as one of the first residents, a year after "brothers R and E Fritts."
Uriah and Susan appear in Sheboygan Co. on Federal censuses from 1850-1880. Eventually Uriah sold his farm to one of his younger sons and moved to Orchard, Iowa, where their daughter Julia lived with her family. According to Iowa Cemetery records collected by the WPA, they are buried at Stillwater Cemetery.
It seems pretty straightforward, and of course, how hard could it be to find Uriah Couse? It's not likely there were too many by that name, especially at that time. Relatively quickly, I was able to locate an abstract of their 1829 marriage announcement: "Married - In Otego, on the 9th ult by David Blakely, Esq., Uriah Couse of Davenport, Delaware County, to Miss Suzan Fritts of Sempronius, Cayuga County." So far, so good - Sempronius is right near Ledyard, so Uriah must have moved up there following the marriage, although I took note of the fact the Davenport and Sempronius are not near each other at all - two hours by car, assuming you have one, which I'm guessing in 1829, Uriah did not.